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However, chronic exposure leads to irreversible neuronal loss and synaptic damage, manifesting as persistent memory, executive functioning, and decision-making deficits (North et al., 2013)

Figure 5 Regulatory Factor, Lipolytic and Lipogenic Pathway Key Markers In order to determine the mechanism of Sirt1/Srebp-1/Ppar pathway-mediated dietary betaine regulation of lipid metabolism, the expression of genes related to several lipid metabolic pathways including regulatory and transcriptional factors, lipolytic pathway and lipogenic pathway were determined in the liver of black seabream juveniles ( Figure 6 )